背景介绍 PTPRM is a member of the protein tyrosine phosphatase family and can participate in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRM has been shown to mediate cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. PTPRM can interact with scaffolding protein RACK1/GNB2L1 and this interaction may be necessary for downstream signaling in response to cell-cell adhesion. PTPRM has been shown to be expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity. 产品介绍 PTPµ (mu) (protein tyrosine phosphatase mu, also known as RPTPµ), catalytic domain, (a.a. 896-1175), (GenBank Accession No. NM_001105244) with N-terminal GST tag, MW=56.2 kDa, expressed in an E. coli expression system.