背景介绍 p70S6K is responsible for the phosphorylation of 40S ribosomal protein S6 and is ubiquitously expressed in human adult tissues. p70S6K is activated by serum stimulation and this activation is inhibited by wortmannin and rapamycin. p70S6k activity undergoes changes in the cell cycle and increases 20-fold in G1 cells released from G0. p70S6K activation requires sequential phosphorylations at proline-directed residues in the putative autoinhibitory pseudosubstrate domain, as well as threonine 389 a site phosphorylated by phosphoinositide-dependent kinase 1 (PDK-1). 产品介绍 Human p70S6Kb1, also known as ribosomal protein S6 kinase, 70 kDa, polypeptide 1 (RPS6KB1), GenBank Accession No. NM_003161, amino acid 1-421 with N-terminal GST tag, MW=74 kDa, expressed in a Baculovirus infected Sf9 cell expression system.