背景介绍 PKLR is a pyruvate kinase which catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP. This reaction is the rate-limiting step of glycolysis. PKLR gene encodes the L- and R-type isoenzymes through alternate splicing events controlled by different promoters. L-type isoform can also appear as a tetramer and is upregulated by glucose with implications in maturity-onset diabetes of the young. 产品介绍 Human pyruvate kinase variant 2 (PKL), GenBank Accession No. NM_181871, full length with N-terminal His-tag 2-543 (end), MW=59 kDa, expressed in an E. coli expression system.