背景介绍 Three types of arginine methylation exist in mammalian cells: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Type I PRMTs ((CARM1, PRMT1, PRMT2, PRMT3, PRMT6, and PRMT8) catalyze ADMA, while type II PRMTs (e.g. PRMTs 5 and 7) catalyze SDMA. Type II PRMTs are found to be strongly implicated in diseases like cancer. For example, PRMT5 plays a role in the repression of certain tumor suppressor genes such as RB tumor suppressors while PRMT7 overexpression is observed in breast cancer 产品介绍 Human PRMT7 (protein arginine methyltransferase 7), GenBank Accession No. NM_019023, a.a. 2-692(end) with N-terminal FLAG-tag, MW=80 kDa, expressed in Sf9 cells using a Baculovirus expression system.