背景介绍 Transcriptional repressor that modulates the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. 产品介绍 Human Polycomb group RING finger protein 6 (PCGF6), GenBank Accession No. NM_001011663, a.a. 2-350 (end), with N-terminal GST-tag, MW=65.7 kDa, expressed in a baculovirus expression system.