背景介绍 TAK1 is a serine/threonine protein kinase that mediates signaling by TGFβ and morphogenetic protein (BMP). In response to IL-1, TAK1 forms a kinase complex with TAB1 and this complex is required for the activation of nuclear factor kappa B (NF-κB). TAK1 can also activate MAPK8/JNK and MAP2K4/MKK4 and thus play a role in the cell response to environmental stress. It has been implicated in various inflammation disorders and cancers, including breast and pancreatic cancer. 产品介绍 The TAK1-TAB1 Kinase Assay Kit is designed to measure TAK1-TAB1 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.