背景介绍 Transmembrane protease, serine 2 is an enzyme that belongs to the serine protease family. It has been implicated as a target in prostate cancer. TMPRSS2 facilitates SARS-CoV-2 particle entry into host cells via S protein priming, and its inhibition blocks virus fusion with angiotensin-converting enzyme 2 (ACE2). This, in turn, restricts SARS-CoV-2 viral entry, making TMPRSS2 an important therapeutic target. 产品介绍 The key to the TMPRSS2 Fluorescent Assay Kit is the fluorogenic substrate. Using this kit, only one simple step on a microtiter plate is required for TMPRSS2 reactions. A sample containing TMPRSS2 is incubated in a reaction mixture with the fluorogenic substrate and fluorescence (λex=383nm, λem=455nm) is measured using a plate reader. Camostat is supplied as a protease inhibitor control.