背景介绍 Cathepsin S is a cysteine protease of the papain family, found inside the lysosomal/endosomal compartments of antigen-presenting cells such as B cells, macrophages and dendritic cells. Cathepsin S participates in the degradation of antigenic proteins to peptides for presentation to the MHC class II. Cathepsin S has additional biological effects, acting as elastase on the surface of vascular endothelial cells, a process that contributes to microvascular complications in diabetes mellitus. 产品介绍 The Cathepsin S Inhibitor Screening Assay Kit is designed to measure the protease activity of Cathepsin S for screening and profiling applications. The Cathepsin S assay kit comes in a convenient 96-well format, with purified Cathepsin S, its fluorogenic substrate, and Cathepsin buffer for 100 enzyme reactions. In addition, the kit includes the cathepsin inhibitor E64 for use as a control inhibitor.