背景介绍 Wee1 is a tyrosine kinase that is overexpressed in many cancer types such as luminal and HER2-positive breast cancer subtypes, hepatocellular carcinomas, and glioblastomas. Wee1 plays a crucial role in regulating the cell division cycle through phosphorylation of CDKs. Inhibiting Wee1 has been shown to prevent the cells from repairing DNA damage due to unchecked replication, suggesting possible combination therapeutics of the DNA damaging reagents and Wee1 inhibitors. 产品介绍 The Wee1 Assay Kit is designed to measure Wee1 activity for screening and profiling applications using Kinase-Glo® Kinase Assay as a detection reagent.