背景介绍 c-Met, also known as HGFR (hepatocyte growth factor receptor), is a receptor protein tyrosine kinase encoded by the gene MET. Upon binding its ligand HGF (hepatocyte growth factor), c-Met activates multiple cellular processes including proliferation, adhesion and angiogenesis. Importantly, many studies report that c-Met is overexpressed in various carcinomas, suggesting that targeting HGF/c-Met signaling could be a promising target for cancer treatment. A splice mutation that results in skipping exon 14 has been identified in ~4% of lung cancer patients, particularly those with non small cell lung cancer. This mutation causes over-expression of MET protein and increased MET activation, leading to oncogenesis. 产品介绍 The c-Met (del 963-1009) Kinase Assay Kit is designed to measure the kinase activity of c-Met (del 963-1009, exon 14 deletion) for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The recombinant protein used in the kit corresponds to amino acids 956-1390 of c-Met that contain the tyrosine kinase domain. The recombinant protein also contains a deletion of amino acids 963-1009 corresponding to exon 14 skipping.