背景介绍 The N540K mutation results in increased FGFR3 autophosphorylation and substrate phosphorylation, and has been linked to hypochondroplasia (short-limbed dwarfism) and impaired chondrocyte differentiation. 产品介绍 Dephosphorylated recombinant FGFR3 (Fibroblast Growth Factor Receptor 3) encompassing amino acids 397-806. This protein contains the pathogenic mutation N540K in the tyrosine kinase domain. It also contains an N-terminal His-Tag. This protein was co-expressed with PTP1B for dephosphorylation. Phosphorylation level confirmed to be <5%. The protein is biotinylated using an N-terminal Avi-Tag™.