背景介绍 DNA polymerase involved in base excision and repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. The protein is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. 产品介绍 Human DNA polymerase ? (beta), also known as Pol beta and POLB (GenBank Accession No. NM_002690), a.a. 2-335 (end), with N-terminal His-tag, MW=39 kDa, expressed in an E. coli cell expression system.