背景介绍 BMI1 (UniProtKB/Swiss-Prot entry P35226) is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of lysine 119 on histone H2A, rendering chromatin heritably changed in its expressibility. BMI1 is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 in the PRC1 complex. 产品介绍 Polyclonal antibody raised in rabbit against mouse BMI1 (BMI1 polycomb ring finger oncogene) using two KLHconjugated synthetic peptides containing a sequence from the central and the C-terminal region of the protein, respectively.