背景介绍 JARID1B (UniProt/Swiss-Prot entry Q9UGL1) is a histone demethylase which specifically demethylates mono-, di, and trimethylated lysine 4 of histone H3. It acts as a transcriptional repressor for the tumor suppressor genes BRCA1 and HOXA5 and has been associated with breast cancer development. In contrast, in melanoma JARID1B itself may function as a tumor suppressor. 产品介绍 Polyclonal antibody raised in rabbit against mouse Jarid1b (Jumonji, AT rich interactive domain 1B), using a KLH-conjugated synthetic peptides containing an amino acid sequence from the central part of the protein.