背景介绍 ALK4 is a member of the subfamily of receptor ser/thr kinases that mediates signaling by the Activins. ALK4 is expressed in many human tissues, including kidney, pancreas, brain, lung, and liver. Truncated ALK4, predominantly expressed in human pituitary adenomas, function as dominant negative receptors to interfere with wild-type receptor function and blocks the antiproliferative effect of activin possibly contributing to development of human pituitary tumors (1). ALK4 is able to mediate Nodal signaling in the presence of Cripto during vertebrate development (2). 产品介绍 Recombinant human activin receptor-like kinase 4, or ALK4 (a.a. 150-end), with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system. The gene accession number is NM_004302.