服务平台拥有丰富的技术服务经验,一流的仪器设备,先进的检测手段和严格的质量控制体系,力求为全球药物研发机构提供优质高效的技术服务

NEK3, GST-tag

货号:40140

规格:10 µg

品牌:

价格:询价

产品概述

背景介绍 NEK3 is a member of the NEK family of protein kinases that share high amino acid homology with NIMA (never in mitosis gene a). NEK3 mRNA is detected in all the proliferating cell lines with the amount not changing during the cell cycle (1). During Prolactin receptor signaling, VAV2 is phosphorylated and activated by NEK3. Overexpression of NEK3 in Chinese hamster ovary cells increases cytoskeletal re-organization in response to Prolactin while downregulation of NEK3 expression by siRNA block these effects (2). Prolactin also stimulates interaction between NEK3 and paxillin leading to increased paxillin phosphorylation, Analysis of breast tissue microarrays show a significant up-regulation of NEK3 expression in malignant versus normal specimens. 产品介绍 Recombinant human NEK3, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
  • 电话:021-54935173
  • 邮箱:marketing@shengzhaobio.com
  • 地址:上海市闵行区罗阳路168号c座305室