背景介绍 ERK2 is a protein serine/threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines (1). Activation of ERK2 requires both tyrosine and threonine phosphorylation that is mediated by MEK. ERK2 is ubiquitously distributed in tissues with the highest expression in heart, brain and spinal cord. Activated ERK2 translocates into the nucleus where it phosphorylates various transcription factors (e.g., Elk-1, c-Myc, c-Jun, c-Fos, and C/EBP beta). 产品介绍 Human ERK2, also known as MAPK1 or MAPKp42, GenBank Accession No. NM_002745, full length, with N-terminal GST-tag, MW ~68 kDa, expressed in E. coli and activated by MEK1 in vitro.