背景介绍 TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family which is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TRKA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermoregulation via sweating in humans. The oncogenic rearrangement of 5'-TPM3-3'-NTRK1 fusion gene has been found in papillary thyroid carcinomas. 产品介绍 Human TPM3-TRKA fusion protein, TPM3 GenBank Accession No. NM_152263, a.a. 1-258, TRKA Genbank Accession No. NM_002529, a.a. 399-end, expressed in an E. coli expression system. TMP3-TRKA MW = 105 kDa.