背景介绍 DLK or mitogen-activated protein kinase kinase kinase 12 is a transmembrane protein containing six epidermal growth factor repeats and is a serine/threonine protein kinase. DLK is involved in the differentiation of several cell types, including adipocytes. DLK plays a role of a tumor suppressor protein and is predominately expressed in neuronal cells. DLK as an activator of the Jnk pathway. Overexpression of DLK results in activation of Jnk1 and the accumulation of a hyperphosphorylated form of c-Jun (1). Postnatal loss of DLK in stem cells and niche astrocytes has been shown to regulate neurogenesis (2). 产品介绍 Recombinant Human DLK, also known as MAP3K12, MUK, and ZPK. Genbank Accession #NM_006301, a.a. 1-520, with an N-terminal GST-tag, MW = 61 kDa, expressed in Sf9 cells via a baculovirus expression system.