背景介绍 UBE2D2(UBC4) Protein or ubiquitin-conjugating enzyme E2D2 is a member of the E2 ubiquitin-conjugating enzyme family which functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. UBE2D2 specifically ubiquitinates E6AP and in vivo inhibition of UBE2D2 can lead to inhibition of E6-stimulated p53 degradation (1). UBE2D2 could conjugate ubiquitin to target proteins in an E6AP-dependent manner. 产品介绍 Recombinant full-length Xenopus UBE2D2, also known as UBC4, PUBC1, UBC4/5, UBCH5B, and E2(17)KB2. Genbank Accession No. NM_001093036, with an N-terminal His-tag, expressed in E. coli. MW=17 kDa.