背景介绍 AMSH (Associated Molecule with the SH3-domain of STAM) is a JAMM domain-containing protein that regulates receptor endosomal sorting of the epidermal growth factor receptor (EGFR). Recombinant AMSH functions as a deubiquitylase in vitro and ablation of AMSH activity by incubation of cells with AMSH siRNA enhances the degradation of EGFR. AMSH mediated cleavage of K63 linked ubiquitin chains is enhanced in the presence of its binding partner STAM. 产品介绍 Human AMSH recombinant protein, full length, with His-tag, expressed in E. coli.