背景介绍 3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2. Blocks EZH2 activity and trimethylation of lysine 27 on histone H3 in vitro. Induces apoptotic cell death in cancer cells and inhibits s-adenosylhomocysteine (SAH) hydrolase. Decreases global DNA methylation and enhances Oct 4 expression in chemically induced pluripotent stem cells (CiPSCs). DZNeP decreased cell migration, which was additionally reduced by DZNeP/gemcitabine combination. 产品介绍 Cell-permeable inhibitor of the histone methyltransferase EZH2.