背景介绍 Donepezil HCl is a piperidine-class AChE inhibitor containing an N-benzylpiperdine and an indanone moiety, which confers it a longer and more selective action against AchE as compared to BuChE (IC50: 7.4 µM). Donepezil HCl has been shown to improve cognitive function of mild to severe moderate AD patients and exhibits excellent tolerability without hepatotoxicity.