背景介绍 Streptozocin, also known as streptozotocin and U-9889, is a small molecule, N-nitroso-containing antibiotic and a potent DNA methylating agent. Streptozocin acts as a nitric oxide (NO) donor and vasorelaxant. In rat cell studies, this compound presented significant methylation of the liver, kidney, and pancreatic cells and selectivity for these cells against the more general methylating activity of the aglycone analog N-methyl-N-nitrosourea . Streptozocin shows particular activity in the pancreas, and has been used both to induce diabetes in mammals and to treat human pancreatic cancers. 产品介绍 Antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cells in vivo.