背景介绍 Tadalafil is a small-molecule inhibitor of phosphodiesterase 5 (PDE5), a predominant PDE in the pulmonary vasculature that hydrolyzes cyclic guanosine monophosphate (cGMP) and is involved in the pathobiology of pulmonary arterial hypertension (PAH). Although it is used for the treatment of erectile dysfunction through oral administration, tadalafil also improves the vasoconstrictive-predominate condition of PAH through elevating cGMP levels in pulmonary vessels resulted from PDE5 inhibition. 产品介绍 Tadalafil, also known as IC351 or Cialis, is a potent, reversible and competitive small-molecule inhibitor of PDE5