背景介绍 TW-37 is a Bcl-2 inhibitor that has been shown to inhibit the angiogenic potential of endothelial cells in vitro. S-phase arrest and apoptosis in pancreatic cancer cell lines have been observed to be induced by TW-37. It binds to the Bcl-2 homology domain 3 (BH3) groove of Bcl-2 preventing the heterodimerization of proapoptotic proteins (such as Bid, Bim, and Bad) with Bcl-2 and subsequently allowing them to induce apoptosis. Recent studies indicate TW-37 is able to inhibit the growth of a broad range of cancer cells (such as breast, prostate, lymphoma, and pancreatic cancer), since it induces S-phase cell cycle arrest with regulation of several important cell cycle related genes, including p27, p57, E2F-1, cdc25A, CDK4, cyclin A, cyclin D1 and cyclin E. 产品介绍 TW-37 is a potent small-molecule inhibitor that attenuates Bcl-2 activation and inhibits multiple Bcl-2 family members including Bcl-xL and Mcl-1. TW-37 also inhibits in vivo and in vitro the activation of Jagged-1 and Notch-1.