背景介绍 Cystic fibrosis transmembrane conductance regulator (CFTR) is a protein that in humans is encoded by the CFTR gene. CFTR is an ABC transporter-class ion channel that transports chloride and thiocyanate ions across epithelial cell membranes. Mutations of the CFTR gene affect functioning of the chloride ion channels in these cell membranes, leading to cystic fibrosis. It is characterized by the triad of chronic bronchopulmonary disease (with recurrent respiratory infections), pancreatic insufficiency (which leads to malabsorption and growth retardation) and elevated sweat electrolytes. 产品介绍 The CFTR-HEK293 Cell Line stably expresses full length, human cystic fibrosis transmembrane conductance regulator (CFTR) protein (GenBank # P13569). A synthetic codon-optimized DNA sequence encoding human CFTR protein with C-terminal Streptavidin-Binding Peptide (SBP) tag is stably integrated in 293HEK-Trex cells.