背景介绍 SIRPα (CD172A, PTPNS1) is a member of the signal-regulatory-protein (SIRP) family, which are transmembrane immunoglobulin receptors that negatively regulate receptor tyrosine kinase-coupled signaling processes. SIRPα is expressed predominantly on macrophages and dendritic cells. Interaction with its ligand CD47 mediates signals that blocks phagocytosis (also known as the "don't eat me" signal). 产品介绍 Recombinant HEK293 cell constitutively expressing full length human SIRPα (#NM_080792). Surface expression is confirmed by flow cytometry.