背景介绍 HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Alternately, interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry. 产品介绍 Recombinant HEK293 stably expressing human HVEM (Herpesvirus entry mediator; CD270; TNFRSF14; ATAR) GenBank Accession # NM_003820).