背景介绍 CD5 is a type-1 transmembrane glycoprotein with an extracellular region composed of three scavenger receptor, cysteine-rich domains. This lymphocytic-specific scavenger receptor functions at the interphase of the innate and adaptive immune responses. It is involved in: (i) microbial-associated pattern recognition; and (ii) modulation of intracellular signals mediated by antigen-specific receptor present in T and B cells.  CD5 is expressed by all T cells and some B cell subsets (B1a and Breg or B10). T cells usually express higher levels of CD5 than B cells, and CD5 is upregulated in T cells upon strong activation. CD5 is a signaling co-receptor, associated with the antigen-specific receptor complex of T and B cells, and down-modulates the activation/differentiation signals delivered upon specific antigen recognition. The signaling pathway used by CD5 is only partially known. 产品介绍 Recombinant CD5-CHO K1 cell line stably expressing a full-length human CD5 receptor (accession number: NM_014207.3). Surface expression of hCD5 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of hCD5 expression (High, Medium and Low) to mimic different stages of cancer target cells with various CD5 expression levels.